PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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7-Bromoheptanoyl chloride
0 ImagesCat. No.: HY-161613CAS No.: 50733-91-0
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1-(2-Bromoethyl)piperazine
0 ImagesCat. No.: HY-W840791CAS No.: 494798-96-8
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N1,N4-dimethylcyclohexane-1,4-diamine
0 ImagesCat. No.: HY-W376544CAS No.: 2678-67-3
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N-(m-PEG4)-N'-(hydroxy-PEG2)-Cy5
0 ImagesCat. No.: HY-141073CAS No.: 2107273-12-9
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tert-Butyl ((3-aminocyclobutyl)methyl)(methyl)carbamate
0 ImagesCat. No.: HY-W539429CAS No.: 1489063-08-2
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(S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline
0 ImagesCat. No.: HY-168303(S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline is a connector for PROTAC, which can be used to synthesize (R)-NX-2127 (HY-153220A) and is utilized in research within the field of malignant tumors.
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4-(2-Aminoethyl)cyclohexan-1-amine
0 ImagesCat. No.: HY-W353339CAS No.: 202256-86-8
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Boc-Octahydrocyclopenta[c]pyrrole-amino
![Boc-Octahydrocyclopenta[c]pyrrole-amino](https://file.medchemexpress.com/product_pic/hy-w043851.gif "Click to View Boc-Octahydrocyclopenta[c]pyrrole-amino Product Detail")
0 ImagesCat. No.: HY-W043851CAS No.: 1031335-28-0
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Di-tert-butyl adipate
0 ImagesCat. No.: HY-W102193CAS No.: 20270-53-5
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tert-Butyl (2-(azetidin-3-yl)ethyl)carbamate
0 ImagesCat. No.: HY-40346CAS No.: 162696-31-3
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11-Hydroxyundecanoic acid
0 ImagesCat. No.: HY-W142804CAS No.: 3669-80-5
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Boc-PEG3-I
0 ImagesCat. No.: HY-W612537CAS No.: 1291090-50-0
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3-{[4-(Dihydroxyboranyl)phenyl]formamido}propanoic acid
![3-{[4-(Dihydroxyboranyl)phenyl]formamido}propanoic acid](https://file.medchemexpress.com/product_pic/hy-w120542.gif "Click to View 3-{[4-(Dihydroxyboranyl)phenyl]formamido}propanoic acid Product Detail")
0 ImagesCat. No.: HY-W120542CAS No.: 2024542-05-8
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tert-Butyl 2-(2-bromoethyl)-7-azaspiro[3.5]nonane-7-carboxylate
![tert-Butyl 2-(2-bromoethyl)-7-azaspiro[3.5]nonane-7-carboxylate](https://file.medchemexpress.com/product_pic/hy-w1115289.gif "Click to View tert-Butyl 2-(2-bromoethyl)-7-azaspiro[3.5]nonane-7-carboxylate Product Detail")
0 ImagesCat. No.: HY-W1115289CAS No.: 2434847-28-4
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15-Bromopentadecanoic acid
0 ImagesCat. No.: HY-W007241CAS No.: 56523-59-2
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Leukotriene B4-d5
0 ImagesCat. No.: HY-107608S1Synonyms: LTB4-d5Leukotriene B4-d5 (LTB4-d5) is deuterium labeled Leukotriene B4. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
